Process for the preparation of new imidazole derivatives,...

Details Process for the preparation of new imidazole derivatives,... Process for the preparation of new imidazole derivatives,...

C - Chemistry, Metallurgy

07

D

167/208, 260/280

C07D 233/61 (2006.01) A61K 31/415 (2006.01) C07D 401/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1324144

Abstract of the disclosure A process for the preparation of new imidazole derivatives of the general formula Image (I) in which Ar denotes phenyl, biphenylyl, naphthyl or thienyl, each of which is optionally substituted by halogen, lower alkyl or lower alkoxy, R1 denotes hydrogen or lower alkyl, Alk denotes straight-chain or branched alkylene having 1 to 10 carbon atoms, .gamma. denotes oxygen, sulfur, sulfinyl or sulfonyl, n denotes one of the numbers 0, 1 or 2, z denotes sulfur or sufinyl, m denotes the number 0 or 1, m being the number 0 when .gamma. denotes sulfur, sulfinyl or sulfonyl, and m being the number 1 when .gamma. denotes oxygen, and R2 denotes cyclohexyl, or denotes phenyl or naphthyl, each of which is optionally substi- tuted by hydroxyl, halogen, trifluoromethyl, lower alkyl or lower alkoxy, or denotes biphenylyl or pyridyl. The imidazole derivatives have excellent antimycotic properties for use in human and veterinary medicine.

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