Process for the preparation of new organ transplants

Details Process for the preparation of new organ transplants Process for the preparation of new organ transplants

A - Human Necessities

61

L

167/322, 167/323

A61L 27/36 (2006.01) A01N 1/02 (2006.01) A61L 2/00 (2006.01)

Patent

CA 1158807

Abstract The organ transplants are intended to be used as a replacement (prostheses) for organs or parts of organs, for examples arteries or veins, which have undergone pathological change or are functionally impaired, The organs, which are taken from a fish, bird or higher mammal, are subjected to crosslinking of the amino groups and of the alcoholic hydroxyl groups of the peptide chains of the intercellular matix by means of a di-, tri- or poly-carboxylic acid It is advantageous subsequently to treat the crosslinked product with a dialdehyde, in order to bind amino groups which have not reacted, or to free the crosslinked product from material which poten- tially may act as an antigen, by hydrolysis with ficin, papain or a protease having a similar action, After the hydrolysis, a comprehensive crosslinking is appro- priately ensured using a dialdehyde or a di-, tri- or poly-carboxylic acid, The resulting prostheses are distinguished by chemical stability, biophysical and biochemical properties similar to those of the natural material and the absence of rejection reactions.

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