Process for the preparation of new thienopyridine derivatives

Details Process for the preparation of new thienopyridine derivatives Process for the preparation of new thienopyridine derivatives

C - Chemistry, Metallurgy

07

D

260/276.1

C07D 495/04 (2006.01)

Patent

CA 1078843

"PROCESS FOR THE PREPARATION OF NEW THIENOPYRIDINE DERIVATIVES" ABSTRACT OF THE DISCLOSURE The present invention relates to a process for the preparation of pyridine derivatives having the formula: Image ( I) in which: R is a phenyl radical substituted with at least an aryl, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or ethylenedioxy group, a styryl, thienyl or benzhydryl radical optionally substi- tuted with at least a halogen atom or a lower alkyl, lower alkoxy, aryl, nitxo, amino, sulfonylamino, carboxy, alkoxycarbonyl, cyano, hydroxymethyl or methylenedioxy group; R1 and R2 repxesent each at least an atom or group selected from hydrogen, halogen anda hydroxy, lower alkyl, lower alkoxy, nitro and amino group; R3 represents hydrogenl halogen, or a hydroxy, lower alkyl, lower alkoxy, nitro or amino group, and n is an integer from 1 to 15, and the symbols R3 may have different meanings in each radical CHR3 when n is greater than 1, and their inorganic or organic acid addition salts and quaternary ammonium derivativos, comprising condensing a tetrahydrothienopyridine of the formula: Image (II) in which R1 and R2 have the above-defined meanings, with a halogen derivative of the formula: X - (CHR3)n-R (III) in which X is a halogen atom, R, R3 and n have the above-defined meanings, and, if desired, hydxolysing or reducing an ester function of the resulting material, to give the compound or the formula (I). Said derivatives are therapeutically valuable in view of their anti-inflammatory, vasodilator and blood-platelet aggregating inhibitor properties. - I -

256470

Affiliated with

Also associated with

Rating

Process for the preparation of new thienopyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of new thienopyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of new thienopyridine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-31776