C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/80 (2006.01) C07B 41/08 (2006.01)
Patent
CA 2282381
The present invention relates to an improved process for the preparation of nicotinic acids represented by structural formula (I) which are prepared by reacting a nicotinic amide compound having formula (a) under acidic conditions with a nitrite salt. In the process of the invention the groups R1, R2, and R3, in the compounds are independently selected from the group consisting of hydrogen and halogen atoms, and R4 is selected from the group consisting of hydrogen, lower alkyl and aryl. The process provides the nicotinic acid compounds in improved yields.
L'invention concerne un procédé amélioré permettant de préparer des acides nicotiniques représentés par la formule structurelle (I), selon lequel on fait réagir un composé d'amide nicotinique de formule (a) avec un nitrite dans des conditions acides. Selon le procédé de l'invention, les groupes R<1>, R<2> et R<3> des composés sont choisis indépendamment dans le groupe comprenant l'hydrogène et les atomes d'halogène, et R<4> est choisi dans le groupe comprenant hydrogène, alkyle inférieur et aryle. Le procédé permet de produire des acides nicotiniques avec un meilleur rendement.
Sharma Padam N.
Vandrevala Marazban H.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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