Process for the preparation of novel isoxazole derivatives

Details Process for the preparation of novel isoxazole derivatives Process for the preparation of novel isoxazole derivatives

C - Chemistry, Metallurgy

07

D

260/304

C07D 413/14 (2006.01)

Patent

CA 1271481

Abstract Process for the preparation of novel substituted isoxazole deri- vatives of the formula Image in which R1 denotes lower alkyl, n denotes the integer 6, 7 or 8, A denotes a group of the formula Image II or III and R2 denotes hydrogen, methyl, chlorine or bromine, this process comprising cyclizing a compound of the formula Image wherein B denotes a group of the formula Image V or VI by treatment with a dehydrating reagent, the oxazole ring being formed. The novel compounds have a pronounced antiviral action and can be used for the treatment and prophylaxis of virus diseases.

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