C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/357.8, 260/2
C07D 311/86 (2006.01) G21F 1/12 (2006.01)
Patent
CA 1069896
ABSTRACT OF THE DISCLOSURE: Xanthones of the general formula: Image (I) and the pharmaceutically acceptable salts and esters thereof wherein A represents a carboxy group; R represents a hydrogen atom, an alkyl group with 1 to 9 carbon atoms, an alkoxy group with 1 to 9 carbon atoms or an alkoxyalkoxy group with 2 to 9 carbon atoms; and X represents a group of the formula: (Ia) or (Ib) Image Image in which R1 represents an alkyl group with 1 to 5 carbon atoms; R2 represents a hydrogen atom, an aliphatic acyl group with 1 to 5 carbon atoms, an aroyl group with 7 or 8 carbon atoms, an aralkyl group with 7 or 8 carbon atoms, a p-toluenesulfonyl group, a radical of the formula -CO-(CH2)n-Het (in which n is an integer from 1 to 3 and Het represents a morpholino or piperidino group), a carbamoyl group, a carboxyalkyl group with 1 to 5 carbon atoms or a radical of the formula -CH=C(COO Alk)2 in which Alk represents an alkyl group with 1-5 carbon atoms; and R3 represents a p-toluenesulfonyl group. The compounds of formula (I) possess interesting anti-allergic activity and are, in particular, of importance in the treatment of allergic asthma and asthmatiform bronchitis of allergic origin.
231004
Barnes Alan C.
Hairsine Peter W.
Ramm Peter J.
Taylor John B.
Roussel-Uclaf
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