Process for the preparation of o-substituted...

Details Process for the preparation of o-substituted... Process for the preparation of o-substituted...

C - Chemistry, Metallurgy

07

C

C07C 239/20 (2006.01) C07D 207/335 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01)

Patent

CA 2168457

In order to prepare O-substituted hydroxylammonium salts having formula (I): R1-CHX-O-NH2 . HL, in which L = halogen, hydrogen sulphate; X = H, alkyl R1 = possibly substituted phenyl, thienyl, furanyl, pyrrolyl or -CR2=CR3R4, in which R2, R3, R4 = H, halogen or alkyl, an acetonoxime-O-alkyl or acetonoxime-O-benzyl ether having formula (II) is reacted with water and a mineral acid H-L while the resulting acetone is continuously removed, and hydrolysis is intermittently carried out at 0-50 °C and under 10-500 mbar pressure. The O-substituted hydroxylammonium salts having the formula (I) are intermediate products for plant protective agents and pharmaceuticals.

Afin de préparer des sels d'hydroxylammonium substitués par oxygène de la formule (I): R<1>-CHX-O-NH2 . HL, dans laquelle L désigne halogène, sulfate d'hydrogène; X désigne H, alkyle; R<1> désigne phényle, thiényle, furanyle, pyrrolyle éventuellement substitués ou -CR<2>=CR<3>R<4>, où R<2>, R<3>, R<4> désignent H, halogène ou alkyle, on fait réagir un éther d'acétonoxime-O-allyle ou d'acétonoxime-O-benzyle de la formule (II) avec de l'eau et un acide minéral H-L, l'acétone qui en résulte étant enlevée en continu. L'hydrolyse est effectuée par intermittence entre 0 et 50 DEG C et sous une pression comprise entre 10 et 500 mbar. Les sels d'hydroxylammonium substitués par oxygène de la formule (I) constituent des produits intermédiaires de produits phytosanitaires et pharmaceutiques.

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