Process for the preparation of oligosaccharide fractions...

Details Process for the preparation of oligosaccharide fractions... Process for the preparation of oligosaccharide fractions...

C - Chemistry, Metallurgy

07

H

260/233

C07H 3/06 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1212942

- 19 - Abstract: Process for the preparation of oligosaccharide fractions having pharmaceutical properties by chemical degradation of heparin Process for the preparation of oligosaccharides and oligosaccharide fractions by degradation of he parin, which comprises submitting to incubation an aqueous solution of heparin containing from 5 to 30 g of heparin/liter in the presence of 4-50 m.moles/1 of cupric acetate and 50-300 m.moles/1 of hydrogen peroxide, at a temperature of 40-50°C, for 20-24 hours and keeping the pH at a value of 7.8 by means of sodium acetate. The obtained products show a high inhibiting property of the Xa factor, a high antithrombotic activity and a very modest anticoagulant activity; therefore they are very interesting for a possible utilization as drugs in the antithrombotic treat- ment, practically free from any risk of haemorrha- ges.

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