Process for the preparation of optically active compounds...

Details Process for the preparation of optically active compounds... Process for the preparation of optically active compounds...

C - Chemistry, Metallurgy

07

C

C07C 309/66 (2006.01) A61K 31/27 (2006.01) C07B 53/00 (2006.01) C07C 37/00 (2006.01) C07C 213/08 (2006.01) C07C 269/04 (2006.01) C07C 39/11 (2006.01) C07C 215/50 (2006.01) C07C 271/44 (2006.01)

Patent

CA 2748349

A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drag substances. In particular, the process relates to the preparation of (S)- 3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as ri-vastigimine and rivastigimine hydrogen tartrate.

Cette invention concerne un procédé catalytique de préparation de composés optiquement actifs et leur conversion ultérieure en substances médicamenteuses souhaitées. En particulier, le procédé concerne la préparation de (S)-3-(1-diméthylaminoéthyl)phénol par réduction catalytique asymétrique et hydrogénation par transfert, ce qui permet d'obtenir un procédé amélioré pour la formation de substances médicamenteuses telles que la rivastigimine et l'hydrogénotartrate de rivastigimine.

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