Process for the preparation of optically-active cyanomethyl...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/06 (2006.01) B01J 31/02 (2006.01) C07C 45/89 (2006.01) C07C 49/88 (2006.01) C07C 255/38 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) C07K 5/12 (2006.01)

Patent

CA 1263800

PROCESS FOR THE PREPARATION OF OPTICALLY-ACTIVE CYANOMETHYL ESTERS Abstract of the Disclosure Stereoisomerically-enriched cyanomethyl esters are prepared by treating a non-symmetrical ketene or an alpha-chiral carboxylic acid halide or reactive derivative thereof with an optically-active alpha- hydroxynitrile. Certain optically-active optionally substituted S-alpha- cyano-3-phenoxybenzyl alcohol intermediates are prepared by treating the corresponding aldehyde or ketone with a source of hydrogen cyanide in the presence of a substantially water-immiscible, aprotic solvent and a cyclo(D-phenylalanyl-D-histidine) as a catalyst.

441540

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