A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/663 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2345818
The invention relates to a process for the preparation of bisphonate- containing pharmaceutical compositions for oral application, wherein the active substance is wet-granulated in manner known per se in a fluidised-bed granulator using adjuvants which have no abrasive action and wherein the wet granulate is then dried in the fluidised bed, screened through a screen having a suitable mesh width and further processed by techniques known per se to form pharmaceutical compositions.
L'invention porte sur un procédé de préparation de compositions pharmaceutiques contenant du bisphonate à administration orale dont le principe actif est granulé par voie humide selon une technique en soi dans un granulateur à lit fluidisé utilisant des adjuvants sans action abrasive, les granulés humides étant ensuite séchés dans le lit fluidisé, tamisés sur un crible aux mailles de dimension appropriée, puis traités par des techniques connues en soi pour former des compositions pharmaceutiques.
Gabel Rolf-Dieter
Mockel Jorn
Woog Heinrich
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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