Process for the preparation of oxazole derivatives

Details Process for the preparation of oxazole derivatives Process for the preparation of oxazole derivatives

C - Chemistry, Metallurgy

07

D

C07D 263/38 (2006.01) C07D 263/48 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2384925

A production method of a compound represented by the formula (see formula I) wherein R1 and R2 are each a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R3 is an electron-withdrawing group, and R4, R5 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof, is provided as an industrially advantageous production method for forming a carbon-carbon bond at the 5-position of oxazole, which method includes reacting a compound represented by the formula (see formula II) wherein the symbols in the formula are as defined above, or a salt thereof, with a compound represented by the formula (see formula III) wherein the symbols in the formula are as defined above, or a salt thereof, in the presence of an acid or a base.

L'invention porte sur un procédé industriel avantageux de formation d'une liaison carbone-carbone à la position 5 de l'oxazole consistant à préparer des composés de formule générale (III) (ou leurs sels) [dans laquelle: R<1> et R<2> sont chacun H, hydrocarbyle facultativement substitué, ou un groupe hétérocyclique facultativement substitué; R<3> est un groupe éliminateur d'électrons; et R<4>, R<5> et R<6> sont chacun H ou hydrocarbyle facultativement substitué] en faisant réagir un composé de formule générale (I) (ou l'un de ses sels), dont les symboles sont définis ci-dessus, avec un composé de formule générale (II) (ou l'un de ses sels) dont les symboles sont définis ci-dessus en présence d'un acide ou d'une base.

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