Process for the preparation of paromomycin derivatives and...

Details Process for the preparation of paromomycin derivatives and... Process for the preparation of paromomycin derivatives and...

C - Chemistry, Metallurgy

07

H

260/230.52

C07H 15/22 (2006.01) C07H 15/232 (2006.01)

Patent

CA 1137982

FC-19 ABSTRACT OF THE DISCLOSURE Process for preparing paromomycin derivatives of the formula (I) Image wherein R1 represents a hydrogen or chlorine atom, and their pharmaceutically acceptable addition salts. Methods of producing these derivatives starting from 4',6'-0-benzylidene-penta-N- benzyloxycarbonylparomomycin is disclosed. The compounds (I) and their pharmaceutically acceptable acid addition salts are useful as active ingredient in therapeutical compositions and as antibiotics for the treatment of amoebic disentery, shigellosis and salmonellosis.

353433

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