Process for the preparation of paroxetine hydrochloride

C - Chemistry – Metallurgy – 07 – D

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C07D 405/12 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2315066

A process for the preparation of paroxetine hydrochloride propan-2-ol solvate comprises forming a solution of paroxetine hydrochloride in a mixture of propan-2-ol and an effective co-solvent, and crystallising paroxetine hydrochloride propan-2-ol solvate from the solution.

Cette invention concerne un procédé de préparation d'un solvat propan-2-ol d'hydrochlorure de paroxetine, lequel consiste à former une solution d'hydrochlorure de paroxetine dans un mélange comprenant du propan-2-ol et un co-solvant efficace. Le solvat propan-2-ol d'hydrochlorure de paroxetine est ensuite cristallisé à partir de cette solution.

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