Process for the preparation of phenyl-guanidine derivatives

Details Process for the preparation of phenyl-guanidine derivatives Process for the preparation of phenyl-guanidine derivatives

C - Chemistry, Metallurgy

07

C

260/470, 260/468

C07C 323/43 (2006.01) C07C 309/15 (2006.01) C07C 315/04 (2006.01) C07C 317/42 (2006.01) C07C 319/20 (2006.01) C07C 381/14 (2006.01) C07C 323/44 (2006.01)

Patent

CA 2035036

- 1 - ABSTRACT The invention relates to a process for the preparation of guanidine-derivatives of the general formula (I) Image (I) wherein R means a C1-4 alkyl group, M means a hydrogenatom, sodium-, potassium-, or calcium ion, A means an -S-, -SO- or -SO2- group; in a way, that th.iocarbamide derivatives of the general formula (II) Image are oxidized optionally in the presence of an inorganic or organic solvent and the sulfonic acid derivative of the general formula (III) Image - 2 - obtained is reacted with an aniline derivative of the general formula (IV) Image (IV) optionally in the presence of an inorganic or organic solvent.

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