Process for the preparation of phosphorothioate triesters

Details Process for the preparation of phosphorothioate triesters Process for the preparation of phosphorothioate triesters

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07F 9/165 (2006.01) C07H 1/00 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01)

Patent

CA 2401083

A process for the synthesis of a phosphorothioate triester is provided. The process comprises the coupling of an H-phosphonate with an alcohol in the presence of a solution comprising both a coupling agent and a sulfur transfer agent. Preferably, the H-phosphorate and alcohol are protected nucleosides or oligonucleotides.

L'inventif concerne un procédé de synthèse d'un triester de phosphorothioate, consistant à coupler un H-phosphonate avec un alcool, en présence d'une solution comprenant à la fois un agent de couplage et un agent de transfert de soufre. De préférence, le H-phosphonate et l'alcool sont des nucléosides ou oligonucléotides protégés.

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