Process for the preparation of physiologically degradable,...

Details Process for the preparation of physiologically degradable,... Process for the preparation of physiologically degradable,...

A - Human Necessities

61

K

167/114, 167/48

A61K 49/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 1187789

Abstract A colloidal solution of human serum albumin is prepared by mixing an aqueous solution of the latter with a non-ionic surface-active agent and an acid solution of a tin(II) salt, adjusting the pH to 3.0 to 8.0 and heating at a constant temperature between 45 and 100°C until com- plete hydrolysis of the tin(II) salt and denaturation of the albumin have taken place; the colloidal solution can also be lyophillzed. By treating the solution or the lyophilizate with a 99m Tc-pertechnetate solution, a colloidal preparation is obtained for scintigraphy of the reticuloendothelial system or the lymphatic system. Alone by suitable pH adjustment, the process makes it possible selectively to obtain colloids with a particle size of, for example, 3.0-0.2 or 0.2-0.03 or below 0.03 µm.

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