C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01)
Patent
CA 2629753
A process for the preparation of a poly(alkoxylated) oligonucleotide is provided. The process comprises reacting an oligonucleotide which has been purified by ultrafiltration with a poly(alkoxide) thereby to form a poly(alkoxylated) oligonucleotide. The poly(alkoxyalted) oligonucleotide may be separated from non-poly(alkoxyalted) oligonucleotide by ultrafiltration under denaturing conditions, such as the presence of organic solvents, for example, ethanol; the presence of urea; the addition of chaotropic salts, for example perchlorate and guanidinium salts; the presence of formamide; and the application of heat, for example a temperature of up to about 70~C.
La présente invention concerne un procédé de préparation d'un oligonucléotide polyalcoxylé. Le procédé comprend la réaction d~un oligonucléotide qui a été purifié par ultrafiltration avec un polyalcoxyde de façon à former ainsi un oligonucléotide polyalcoxylé. L'oligonucléotide polyalcoxylé peut être séparé de l'oligonucléotide non-polyalcoxylé par ultrafiltration dans des conditions de dénaturation, telles que la présence de solvants organiques, par exemple, l~éthanol ; la présence d~urée ; l'addition de sels chaotropiques, par exemple des sels de perchlorate et de guanidinium ; la présence de formamide ; et en chauffant, par exemple, à une température allant jusqu'à environ 70 °C.
Kuchimanchi Satya
Shaikh Saied
Sinha Nanda Dulal
Avecia Biotechnology Inc
Smart & Biggar
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