Process for the preparation of prostaglandin derivatives

Details Process for the preparation of prostaglandin derivatives Process for the preparation of prostaglandin derivatives

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01)

Patent

CA 2751686

The invention concerns a new process for the preparation of prostaglandin derivatives, in particular prostaglandin F2.alpha. derivatives, for example bimatoprost, latanoprost and travoprost, the new intermediates of said process and their use in the preparation of prostaglandin derivatives. Said process comprises: a) reacting compounds of formula (I) with compounds of formula (II) to give compounds of formula (III) b) reducing with an asymmetric reducing agent the oxo group of the side chain of compounds of formula (III) to give compounds of formula (IV)

La présente invention concerne un nouveau procédé pour la préparation de dérivés de prostaglandine, en particulier des dérivés de prostaglandine F2a, par exemple le bimatoprost, le latanoprost et le travoprost, les nouveaux intermédiaires dudit procédé et leur utilisation dans la préparation de dérivés de prostaglandine. Ledit procédé comprend : a) la réaction de composés de formule (I) avec des composés de formule (II) pour obtenir des composés de formule (III) b) la réduction avec un agent réducteur asymétrique du groupe oxo de la chaîne latérale de composés de formule (III) pour obtenir des composés de formule IV.

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