Process for the preparation of prostanoids

C - Chemistry – Metallurgy – 07 – C

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260/356, 260/583

C07C 49/707 (2006.01) C07C 45/29 (2006.01) C07C 45/65 (2006.01) C07C 45/67 (2006.01) C07C 62/32 (2006.01) C07D 309/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1164006

ABSTRACT OF THE DISCLOSURE Compounds of the general formula I are disclosed as useful intermediates in the preparation of prostanoids: Image I (wherein A represents O or H, ORz; Rz represents h?drogen or a protecting group; Rx represents ?drogen or a protecting group; and Ry represents halogen, a substituted thio group, di-substituted amino group, or a group of the formula R2, and R2 represents a straight-or branched-chain alkyl alkenyl or alkynyl group which may optionally be substituted by one or more carboxyl, carboxylic acid ester, or free or protected hydroxyl, thiol, aldehyde or keto groups; with the provisos that Rx is not hydrogen when A is O and Ry is R2; and that when A is H, ORz Ry is R2 and Rx and Rz are not both hydrogen. Processes for the preparation of these compounds and of 2-substituted 4-hydroxy-cyclopent-2-en-1-one derivatives are also disclosed.

334748

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