Process for the preparation of pure citalopram

Details Process for the preparation of pure citalopram Process for the preparation of pure citalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) A61K 31/343 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2360303

The present invention relates to a process for the prepara- tion and purification of citalopram (I) in which a compound of Formula (II) wherein Z is iodo, bromo, chloro or CF3-(CF2)n -SO2-O-, n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction with a cyanide source; the resultant crude citalopram product is optionally sub- jected to some initial purification and subsequently treated with an amide or an amide-like group forming agent; the reaction mixture is then sub- jected to an acid/base wash and/or crystallisation and recrystallisation of citalopram in order to remove the amides formed from the crude citalo- pram mixture; and the resulting citalopram product is optionally further purified, worked up and isolated as the base or a pharmaceutically accept- able salt thereof.

L'invention concerne un procédé de préparation et de purification du citalopram (I). Dans le composé de la formule (II), Z est iodo, bromo, chloro ou CF3-(CF2)n-SO2-O-, n étant 0, 1, 2, 3, 4, 5, 6, 7 ou 8, est soumis à une réaction d'échange de cyanure avec une source de cyanure. Le produit citalopram brut résultant est éventuellement soumis à une première purification, puis traité avec un agent formant un groupe amide ou analogue. Le mélange de la réaction est alors soumis à un lavage acide/base et/ou une cristallisation et recristallisation du citalopram afin d'éliminer les amides formés à partir du mélange de citalopram brut. Enfin, le produit de citalopram obtenu est éventuellement purifié une nouvelle fois, travaillé et isolé en tant que base ou sel pharmaceutiquement acceptable de celle-ci.

Affiliated with

Also associated with

Rating

Process for the preparation of pure citalopram does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of pure citalopram, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of pure citalopram will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1707870