Process for the preparation of purified bacterial membranal...

C - Chemistry – Metallurgy – 12 – P

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167/135, 530/15.

C12P 21/00 (2006.01) A61K 35/74 (2006.01) A61K 39/02 (2006.01)

Patent

CA 1139302

ABSTRACT OF THE DISCLOSURE This invention relates to a process for the preparation of purified bacterial membranal proteog- lycans. The process comprises at least one step in which crude proteoglycans are treated in aqueous medium with a base or a hypobromite, followed by elimination of the excess reactant and the insoluble residue, the purified proteoglycans being present in aqueous solution. The thus obtained purified proteoglycans may be used as immunity adjuvants in vaccines without causing side-effects such as pyrogenic reactions.

341674

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