Process for the preparation of pyrimidine compounds

Details Process for the preparation of pyrimidine compounds Process for the preparation of pyrimidine compounds

C - Chemistry, Metallurgy

07

D

C07D 239/34 (2006.01) C07D 239/52 (2006.01) C07D 307/83 (2006.01)

Patent

CA 2095848

A process for preparing agrochemical intermediates of formula (I), wherein W is (CH3O)2CH.CHCO2CH3 or CH3O.CH = CCO2CH3; Z1 is a halogen atom; and R1, R2, R3 and R4 are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, acetoxy or acyl; the process comprising the steps of: (a) reacting a compound of formula (II), wherein X, R1, R2, R3 and R4 are as defined above, with a compound of formula ROCH3, wherein R is a metal; and, (b) reacting the product of (a) with a compound of formula (III), wherein Z1 and Z2 are halogen atoms. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (II) wherein R1, R2, R3 and R4 are all hydrogen.

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