Process for the preparation of pyrimido- and imidazo...

Details Process for the preparation of pyrimido- and imidazo... Process for the preparation of pyrimido- and imidazo...

C - Chemistry, Metallurgy

07

D

260/271, 260/242

C07D 471/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1129854

ABSTRACT Pyrimido- nnd imidazo-pyridoindole derivatives, in the form of racemates or optically active isomers, of formula: Image (I) in which n = 0 or 1, R1 = H, Hal, alkyl or alkoxy or CF3, R2 = H, alkyl, cycloalkyl-alkyl, cycloalkyl, N,N-dialkyl- aminoalkyl or phenyl, R3 = H or alkyl and R4 = H, alkyl or benzyl are useful as anti-anoxia or psychotropic agents in therapy. They are prepared by cyclising a compound of formula: Image (II) wherein R5 is alkyl, by heating it in an acidic medium, such as ethanolic hydrogen chloride.

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