C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/285, 260/266
C07D 401/10 (2006.01) C07D 215/56 (2006.01) C07F 5/02 (2006.01)
Patent
CA 1306750
A B S T R A C T The invention relates to a new process for the pre- paration of compounds of the general Formula I Image /I/ (wherein R stands for hydrogen or methyl) and pharma- ceutically acceptable salts thereof which comprises reacting a compound of the general formula V Image /V/ (wherein R1 and R2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally sub- stituted by halogen; or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the general Formula VI Image /VI/ (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the general Formula VII /VII/ Image thus obtained (wherein R, R1 and R2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt. The compounds of the general Formula I are known antibacterial agents. The advantage of the process of the present inven- tion is that it makes the desired compounds of the ge- neral Formula I available in a simple manner, with high yields and in a short reaction time.
524724
Balogh Maria
Hermecz Istvan
Horvath Agnes
Kereszturi Geza
Kovacs Gabor
Chinoin Gyogyszer - Es Vegyeszeti Termekek Gyara Rt
Fetherstonhaugh & Co.
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