Process for the preparation of quinolylpropenal

Details Process for the preparation of quinolylpropenal Process for the preparation of quinolylpropenal

C - Chemistry, Metallurgy

07

D

C07D 215/14 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2398138

3-[2-Cyclopropyl-4-(4-fluorophenyl)-3- quinolyl]prop-2-enal of the below formula (see above formula) is prepared in a high yield by reducing 3-[2-cyclopropyl-4- (4-fluorophenyl)-3-quinolyl]prop-2-enenitrile with Raney nickel either in the presence of formic acid and 0.25 to 1 part by volume of water per part by volume of formic acid or in the presence of both an amine salt of formic acid and an organic acid.

La présente invention concerne un procédé de préparation de 3-[2-cyclopropyl-4-(4-fluorophényl)-3-quinolyl]prop-2-énal à rendement considérable par réduction de 3-[2-cyclopropyl-4-(4-fluorophényl)-3-quinopropyl]prop-2-enitrile avec du nickel de Raney soit en présence de l'acide formique et de 0.25 à 1 partie en volume d'eau par partie en volume d'acide formique ou en présence à la fois d'un sel aminé d'acide formique et d'un acide organique.

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