Process for the preparation of r-2,2-r-,r--1,3-...

Details Process for the preparation of r-2,2-r-,r--1,3-... Process for the preparation of r-2,2-r-,r--1,3-...

C - Chemistry, Metallurgy

12

P

195/129, 195/65,

C12P 41/00 (2006.01) C07D 317/20 (2006.01) C07D 317/32 (2006.01) C07D 317/72 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12P 17/04 (2006.01)

Patent

CA 1334082

Process for the preparation of R-2,2-R1,R2-1,3-dioxolane-4- methanol wherein R1 and R2 are H or alkyl groups or wherein R1 and R2 together with the carbon atom to which they are attached form a carbocyclic ring by subjecting a mixture of R- and S-2,2-R1,R2-1,3-dioxolane-4-methanol to the action of a micro-organism or substances derived therefrom having the ability for stereoselective consumption of S-2,2-R1,R2-1,3- dioxolane-4-methanol preferably until at least 80 wt% and more preferably all the S-2,2-R1,R2-1,3-dioxolane-4-methanol is consumed. Various micro-organisms of the genus Rhodococcus, Nocardia and Corynebacterium are disclosed as suitable for the purpose. The R-isomer is a valuable intermediate for stereospecific synthesis of various biologically active compounds including S-metoprolol.

536709

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