Process for the preparation of (r)- or (s)-aminocarnitine...

Details Process for the preparation of (r)- or (s)-aminocarnitine... Process for the preparation of (r)- or (s)-aminocarnitine...

C - Chemistry, Metallurgy

07

C

C07C 227/16 (2006.01) C07C 229/26 (2006.01) C07C 231/02 (2006.01) C07C 231/10 (2006.01) C07C 233/47 (2006.01) C07C 273/18 (2006.01)

Patent

CA 2453019

A process for the production of (R)- or (S)-aminocarnitine starting respectively from (R)- or (S)-nitryloxycarnitine, through the formation and hydrogenation of the azidocarnitine intermediate with the same absolute configuration is described. (R)-aminocarnitine inner salt is obtained after purification, which is then converted into non-deliquescent salts. A further subject of the present invention is a process for the preparation of derivatives of (R)- and (S)-aminocarnitine, in particular acylated or ureic derivatives, having known pharmacological properties, starting from (R)- and (S)-aminocarnitine salts, releasing the aminic function in situ.

Procédé servant à préparer (R)- ou (S)-aminocarnitine à partir de (R)- ou (S)-nitryloxycarnitine respectivement au moyen de la formation et de l'hydrogénation de l'intermédiaire azidocarnitine présentant la même configuration absolue. On obtient le sel interne de (R)-aminocarnitine après purification, puis on le convertit en sels non-déliquescents. L'invention concerne également un procédé servant à préparer des dérivés de (R)- et (S)-aminocarnitine, en particulier des dérivés acylés ou uréiques, possédant des propriétés pharmacologiques connues, à partir de sels de (R)- et (S)-aminocartinine, ce qui libère la fonction aminique in situ.

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