Process for the preparation of resin-bound cyclic peptides

Details Process for the preparation of resin-bound cyclic peptides Process for the preparation of resin-bound cyclic peptides

C - Chemistry, Metallurgy

07

K

C07K 1/04 (2006.01) C07K 7/54 (2006.01) C07K 14/635 (2006.01)

Patent

CA 2325572

This invention is directed to a process for the solid phase, fragment-based synthesis of resin-bound cyclic peptide analogs of parathyroid hormones and analogs of parathyroid hormone-related proteins, which analogs contain at least one bridge between the side chains of two non-adjacent amino acid residues, and to peptide fragments useful therefor.

La présente invention concerne un procédé permettant la synthèse en phase solide sur base de fragments d'analogues de peptides cycliques à liaison résinique d'hormones parathyroïde, et d'analogues de protéines en liaison avec une hormone parathyroïde. En l'occurrence, ces analogues contiennent au moins un pont entre les chaînes latérales de deux radicaux acides aminés non adjacents. L'invention concerne également des fragments de peptides convenant particulièrement pour un tel procédé.

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