Process for the preparation of rho-kinase inhibitor compounds

Details Process for the preparation of rho-kinase inhibitor compounds Process for the preparation of rho-kinase inhibitor compounds

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4725 (2006.01) C07C 69/78 (2006.01)

Patent

CA 2726611

The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV, and XV. Such compounds are useful as final products or can be used as intermediates and be further modified to prepare other desired products such as rho-kinase inhibitors. The present invention is also directed to certain novel compounds and/or novel solid forms of certain compounds.

L'invention concerne des processus synthétiques pratiques à haut rendement pour la préparation de composés de formule générale III, IV, V, VII, VIII, IX, X, XII, XIV et XV. De tels composés sont utiles en tant que produits finis ou quintermédiaires qui peuvent être modifiés pour préparer d'autres produits souhaités tels que des inhibiteurs de rho-kinase. L'invention concerne également certains composés nouveaux et/ou certaines formes solides nouvelles de certains composés.

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