C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/4196 (2006.01) A61P 25/06 (2006.01)
Patent
CA 2688463
The present invention relates to a novel process for the preparation of rizatriptan and its pharmaceutically acceptable salts. It provides a novel process for the preparation of highly pure rizatriptan, which can be easily adopted for commercial production with a high degree of consistency in purity and yield. Subsequently the rizatriptan base preparedcan be converted into any suitable pharmaceutically acceptable salt, such as the oxalate, succinate or benzoate salt,for dosage form preparation. The present invention also provides a composition comprising rizatriptan useful for the manufacture of a medicament for the treatment or prevention of migraine.
La présente invention concerne un nouveau procédé de préparation de rizatriptane et ses sels pharmaceutiquement acceptables. Elle propose un nouveau procédé de préparation de rizatriptane hautement pur, qui peut être facilement adopté pour la production commerciale, avec un degré élevé de constance en termes de pureté et de rendement. Ensuite, la base de rizatriptan préparée peut être convertie en tout sel approprié pharmaceutiquement acceptable, tel que les sels d'oxalate, de succinate ou de benzoate, pour la préparation de formes galéniques. La présente invention concerne également une composition comprenant le rizatriptane, utile pour la production d'un médicament pour le traitement ou la prévention de la migraine.
Gore Vinayak G.
Kulkarni Vikas S.
Wavhal Sneha R.
Generics [uk] Limited
Osler Hoskin & Harcourt Llp
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