Process for the preparation of rosiglitazone

Details Process for the preparation of rosiglitazone Process for the preparation of rosiglitazone

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01)

Patent

CA 2566352

The present invention relates to a process for the preparation of 5-{4-[2-(N- methyl-N-(2-pyridyl)amino)ethoxy]benzyl-2,4-thiazolidinedione of formula (I) (Rosiglitazone), which comprises the reaction of 5-{4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxyl]benzylidene-2,4-thiazolidinedione of formula (II), with a 1,4-dihydropyridine of general formula (III).

La présente invention concerne un procédé destiné à la préparation d'une 5-{4-[2-(N-méthyl-N-(2-pyridyl)amino)éthoxy]benzyl-2,4-thiazolidinedione représentée par la formule générale (I) (Rosiglitazone), consistant à faire réagir la 5-{4-[2-(N-méthyl-N-(2-pyridyl)amino)éthoxyl]benzylidène-2,4-thiazolidinedione représentée par la formule générale (II) avec une 1,4-dihydropyridine représentée par la formule générale (III).

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