Process for the preparation of rosuvastatin salts

Details Process for the preparation of rosuvastatin salts Process for the preparation of rosuvastatin salts

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2749727

The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-iso-propyl-2- (methanesulphonyl-methyl-amino)- pyrimidin-5-yl]-(3R,51S)- dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.

La présente invention concerne un nouveau procédé de synthèse des sels de la rosuvastatine [acide 7-[4-(4-fluorophényl)-6-isopropyl-2-(méthanesulfonyl-méthyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-énoïque] de formule (I) formés avec des cations divalents, préférentiellement avec des ions de calcium ou de zinc, ledit procédé étant caractérisé en ce que le sel de tert-butylammonium de la rosuvastatine réagit avec le cation divalent approprié, préférentiellement avec des ions de calcium ou de zinc, dans un mélange d'eau et d'un solvant organique immiscible ou légèrement miscible à l'eau, et en ce que le sel formé est isolé.

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