Process for the preparation of sevelamer hydrochloride and...

A - Human Necessities – 61 – K

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A61K 31/785 (2006.01) A61K 9/16 (2006.01) A61P 13/12 (2006.01) C08J 3/12 (2006.01) C08L 39/02 (2006.01) C08F 26/02 (2006.01)

Patent

CA 2661987

Disclosed herein is an improved process for preparation of Sevelamer hydrochloride having phosphate binding capacity of 4.7 to 6.4mmol/g. Further, the invention discloses Sevelamer hydrochloride compositions and a novel process for preparation of said compositions comprising high shear non-aqueous granulation.

La présente invention concerne un procédé amélioré de préparation d'hydrochlorure de Sevelamer ayant une capacité de liaison du phosphate de 4,7 à 6,4 mmol/g. En outre, l'invention propose des compositions d'hydrochlorure de Sevelamer et un procédé inédit de préparation desdites compositions comprenant une granulation non aqueuse sous haut cisaillement.

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