Process for the preparation of somatostatin

Details Process for the preparation of somatostatin Process for the preparation of somatostatin

C - Chemistry, Metallurgy

07

K

530/7.26

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1137467

52 ABSTRACT OF THE DISCLOSURE The present invention relates to a new process for the stepwise preparation of somatostatin enabling a product of high purity to be obtained, with high yields, from cysteine in 14 position whose acid function is protected by the phenylazobenzylsufonyl- ethyloxy group and thiol function is protected by the acetamidomethyl group, all the peptide coupling reactions being effected in liquid phase in the dimethyl- formamide, the intermediate peptides being precipitated by addition of a second solvent and purified in solid phase by washing with the aid of suitable solvents dissolving the impurities.

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