Process for the preparation of statins

Details Process for the preparation of statins Process for the preparation of statins

C - Chemistry, Metallurgy

07

D

C07D 309/30 (2006.01)

Patent

CA 2545316

The invention relates to a method for the production of a statin. Said method comprises the following steps: a) a compound of formula (II) is produced, wherein S1 represents a hydrogen atom or a hydroxyl protective group, S2 and S3 independently represent a hydroxyl protective group and R1 represents a hydrogen atom or a carboxyl protective group. Said compound of formula (II) is produced by stereoselective hydrogenation of a compound of formula (III) in order to form a compound of formula (II-a) and, optionally, by introducing a hydroxyl protective group. b) by lactonising the compound of formula (II) in order to form a compound of formula (I-a).

L'invention concerne un procédé de fabrication d'une statine consistant a) à fabriquer un composé de formule (II), S?1¿ étant un atome d'hydrogène ou un groupe de protection hydroxyle, S?2¿ et S?3¿ étant indépendamment l'un de l'autre un groupe de protection hydroxyle, et R?1¿ étant un atome d'hydrogène ou un groupe de protection hydroxyle, par hydrogénation sélective d'un composé de formule (III) en composé de formule (II-a) et introduction éventuelle d'un groupe de protection hydroxyle; et b) à lactoniser le composé de formule (II) en composé de formule (I-a).

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