Process for the preparation of steroidal derivatives of...

Details Process for the preparation of steroidal derivatives of... Process for the preparation of steroidal derivatives of...

C - Chemistry, Metallurgy

07

J

260/19

C07J 43/00 (2006.01)

Patent

CA 1037466

ABSTRACT OF THE DISCLOSURE: The present invention relates to a process for the preparation of the esters of [(1-benzyl-1H-indazol-3-yl)-oxy]- acetic acid at primary hydroxyl in position 21 of hydrocortisone, cortisone, prednisone and prednisolone, characterized by the fact that cortisone, hydrocortisone, prednisone and predniso- lone are reacted at room temperature with [(1-benzyl-1H-indazol- 3-yl)-oxy]acetyl chloride in the presence of an HC1 acceptor. The substances as produced by the process defined above present a spectrum of anti-inflammatory effects. They inhibit a wide band of pathologic responses ranging from the prevailingly pro- ductive and vascular ones and those having a degenerative and necrotic character.

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