Process for the preparation of strontium ranelate

Details Process for the preparation of strontium ranelate Process for the preparation of strontium ranelate

C - Chemistry, Metallurgy

07

D

C07D 333/38 (2006.01) A61K 31/381 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2619720

A process for the preparation of strontium ranelate or a hydrate thereof is provided comprising (a) reacting a tetraester compound of Formula II: wherein R, R1, R2, and R3 are independently a linear or branched C1-C6alkyl group or a substituted or unsubstituted C3-C12 cyclic group, in the presence of a lithium base and in a solvent with an inorganic acid salt of strontium.

L'invention concerne un procédé permettant de préparer du ranélate de strontium ou d'un hybride de ce dernier, qui consiste (a) à faire réagir un composé tétraester de la formule II, dans laquelle R, R1, R2, et R3 représentent indépendamment un groupe C1-C6 alkyle linéaire ou ramifié ou un groupe cyclique C3-C12 substitué ou non substitué, en présence d'une base lithium et dans solvant avec un sel d'acide inorganique de strontium.

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