Process for the preparation of submicroscopic particles, the...

Details Process for the preparation of submicroscopic particles, the... Process for the preparation of submicroscopic particles, the...

A - Human Necessities

61

K

167/166

A61K 9/14 (2006.01) A61K 9/51 (2006.01) B01J 13/14 (2006.01)

Patent

CA 1205015

ABSTRACT OF THE DISCLOSURE The present invention provides for a process for the preparation of submicroscopic particles formed of a polymerized alkyl cyanoacrylate and containing a biologically active sub- stance. At least one alkyl cyanoacrylate, in which the term "alkyl" denotes an alkyl radical having 1 to 12 carbon atoms, is added, with stirring, to pure water or to an aqueous solution or aqueous colloidal solution of an acid and/or of another water- soluble substance, and the stirring is continued until substan- tially all the alkyl cyanoacrylate has been converted to sub- microscopic particles formed of polyalkyl cyanoacrylate; a bio- logically active substance is introduced into the reaction medium before the introduction of the monomer or after the for- mation of the submicroscopic particles. The submicroscopic particles are useful as carriers for substances such as medi- cinal substances or products for diagnosis.

401581

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