C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/303, 260/266
C07D 271/04 (2006.01) C07D 413/02 (2006.01)
Patent
CA 1192905
ABSTRACT OF THE DISCLOSURE There is provided a novel process for making novel sub- stituted 3-amino-sydnonimines of the general formula I Image (I) and their pharmacologically acceptable acid addition salts, wherein R1 denotes the radical Image or the radical Image R2 denotes hydrogen or the radical -Co-R4, R3 denotes methyl, ethyl, propyl or isopropyl and R4 denotes an aliphatic radical with 1 to 4 C atoms, which can also be substituted by alkoxy with 1 to 3 C atoms, or denotes a cycloaliphatic radical with 5 to 7 C atoms, a bicycloaliphatic radical with 7 to 14 C atoms, a tricycloalipha- tic radical with 7 to 16 C atoms, an alkoxy radical with 1 to 6 C atoms, an aryloxy radical with 6 to 12 C atoms, an alkoxycarbonyl radical with a total of 2 to 7 C atoms, an aryl radical with 6 to 12 C atoms, or an aryl radical which has 6 to 12 C atoms and is monosubstituted, disubstituted or trisubstituted by 1 to 3 halogen atoms and/or 1 to 3 alkyl radicals with 1 to 3 atoms and/or 1 to 3 alkoxy radicals with 1 to 3 C atoms and/or 1 or 2 nitro groups. Such novel compounds are useful in the treatment of cardiovascular diseases such as hypertension and angina pectoris.
397186
Beyerle Rudi
Bohn Helmut
Just Melitta
Martorana Piero A.
Nitz Rolf-Eberhard
Cassella Aktiengesellschaft
Fetherstonhaugh & Co.
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