Process for the preparation of substituted 4-hydroxycoumarins

C - Chemistry – Metallurgy – 07 – D

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C07D 311/56 (2006.01)

Patent

CA 2155127

A process for preparing compounds of general formula (I) wherein R is selected from hydrogen, phenyl, substituted phenyl, alkyl and substituted alkyl groups comprises reacting 4-hydroxycoumarin and a substituted tetralol of general formula (II) wherein R is as defined above, in the presence of an aromatic hydrocarbon and a catalyst.

L'invention se rapporte à un procédé de préparation de composés de la formule générale (I), dans laquelle R est choisi parmi hydrogène, phényle, phényle substitué, alkyle, et des groupes alkyles substitués, ce procédé consistant à faire réagir la 4-hydroxycoumarine avec un tétralol substitué de la formule générale (II), danslaquelle R est tel que défini ci-dessus, en présence d'un hydrocarbure aromatique et d'un catalyseur.

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