Process for the preparation of substituted pentaalkylchromenes

Details Process for the preparation of substituted pentaalkylchromenes Process for the preparation of substituted pentaalkylchromenes

C - Chemistry, Metallurgy

07

D

C07D 311/72 (2006.01) C07C 46/08 (2006.01) C07C 50/24 (2006.01) C07D 311/58 (2006.01) C07D 311/70 (2006.01)

Patent

CA 2082003

ABSTRACT OF THE DISCLOSURE A novel process is disclosed for the preparation of pentaalkylchromenes of the general formula: Image (I) wherein each R denotes a lower alkyl group having from 1 to 4 C atoms and R1 denotes a phenyl group which is unsubstituted or substituted by a lower alkyl group having from 1 to 4 C atoms, by halogen or by a nitro group, or an alkanoyl group having from 1 to 4 C atoms. In the process, a trialkylhydroquinone is reacted with a halogenated butenol to give a substituted tetraalkylhydroquinone, which is oxidised and then the halogen atom is substituted with a suitable nucleophile. The resulting compound is finally cyclised to give the final product of formula I. The pentaalkylchromenes I are suitable intermediates for the preparation of hypolipidaemic pharmaceuticals.

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