Process for the preparation of substituted quinolines

Details Process for the preparation of substituted quinolines Process for the preparation of substituted quinolines

C - Chemistry, Metallurgy

07

C

260/611, 260/319

C07C 205/09 (2006.01) C07D 209/34 (2006.01)

Patent

CA 1332948

A process which comprises reductive cyclisation of a compound of structure (II) Image (II) in which n is 1 to 3 and X is a group displaceable by amine in the presence of at least two equivalents of anhydrous iron (III) chloride and at least two equivalents of an acetyl halide and a solvent to form a compound of structure (III) Image (III) in which X and n are as hereinabove defined, Z is halogen.

616469

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