Process for the preparation of substituted thiazoles

Details Process for the preparation of substituted thiazoles Process for the preparation of substituted thiazoles

C - Chemistry, Metallurgy

07

D

C07D 277/56 (2006.01)

Patent

CA 2533658

This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5- carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a class of substituted thiazoles that inhibit xanthine oxidase and thus block uric acid production.

L'invention concerne des procédés de production de thiazoles substitués. Le thiazole substitué, 2-(4-hydroxyphényl)-4-méthyl-1,3-thiazole-5-carboxylate d'éthyle selon l'invention, également appelé TEI-6720, est utilisé dans le traitement de la goutte et de l'hyperuricémie. Ce composé appartient à une catégorie de thiazoles substitués qui inhibent la xanthine oxydase et bloquent ainsi la production d'acide urique.

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