Process for the preparation of sufentanil derivatives by...

Details Process for the preparation of sufentanil derivatives by... Process for the preparation of sufentanil derivatives by...

C - Chemistry, Metallurgy

07

D

C07D 409/06 (2006.01) C07D 211/66 (2006.01) C07D 401/06 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2167912

A piperidine derivative such as sufentanil is formed in a process which includes dichloro carbene addition to 4-piperidone and subsequent aminolysis to form a 4-amino-4-carbamoyl piperidine (Formula 1).

Un dérivé de pipéridine, tel que le sufentanil, est obtenu dans un procédé consistant à ajouter du dichlorocarbène à 4-pipéridone et à effectuer ensuite une aminolyse pour obtenir une 4-amino-4-carbamoyle pipéridine (formule 1).

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