C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) C07D 235/00 (2006.01) C07D 253/00 (2006.01)
Patent
CA 2431933
The present invention relates to a process for the preparation of sulphonamide--substituted imidazotriazinones of the general formula (I) (see formula I) characterized in that compounds of the formula (II) (see formula II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
La présente invention concerne un procédé de production d'imidazotriazinones à substitution sulfonamide, de formule générale (I). Ce procédé est caractérisé en ce que des composés de formule (II) sont mis en réaction avec de l'acide sulfurique, les produits obtenus sont mis en réaction avec du chlorure de thionyle, puis sont mis en réaction in situ dans un solvant inerte avec une amine, afin de donner les composés selon cette invention et éventuellement les sels, hydrates ou N-oxydes correspondants.
Gehring Reinhold
Heilmann Werner
Nowakowski Marc
Wahl Karl-Heinz
Aktiengesellschaft Bayer
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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