Process for the preparation of sustained release pellets

Details Process for the preparation of sustained release pellets Process for the preparation of sustained release pellets

A - Human Necessities

61

K

A61K 9/16 (2006.01)

Patent

CA 2132451

A process for the manufacture of sustained release pellets comprising pelletizing a mixture containing the drug in finely di- vided form and a binder. The characteristic feature is that: (a) said binder is in particle form consisting of one ar more water-in- soluble wax-like binder substance(s) with a melting point above 40 °C, and (b) said pelletization step is performed by mechanical- ly working said mixture, in a high shear mixer, under the input of a sufficient amount of energy for the binder to melt and pelletization to take place.

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