Process for the preparation of symmetrical 1,4-...

Details Process for the preparation of symmetrical 1,4-... Process for the preparation of symmetrical 1,4-...

C - Chemistry, Metallurgy

07

D

260/294.2

C07D 211/90 (2006.01) C07C 205/56 (2006.01)

Patent

CA 1234573

ABSTRACT OF THE DISCLOSURE In the preparation of a 1,4-dihydropyridine of the formula Image in which R is a phenyl radical which is optionally sub- stituted once or twice by nitro and/or chlorine, R1 is a C1-C1-alkyl radical which is optionally substituted by a C1-C4-alkoxy group by preparing an ylidene compound of the formula Image and reacting such ylidene compound with an enamine compound of the formula Image the improvement which comprises preparing the ylidene compound by reaction of a ketocarboxylic ester of the formula Image with an aldehyde of the formula RCHO, in a solvent in the presence of a catalyst amount of any acetate salt of an amine at a tem- perature from about -10°C up to 100°C. Le A 22 066

451158

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