Process for the preparation of tamsulosin and related compounds

Details Process for the preparation of tamsulosin and related compounds Process for the preparation of tamsulosin and related compounds

C - Chemistry, Metallurgy

07

C

C07C 303/40 (2006.01) A61K 31/18 (2006.01) A61P 13/08 (2006.01) C07C 311/37 (2006.01)

Patent

CA 2627133

The invention relates, in general, to the preparation of (R)(-)tamsulosin free base by reaction of (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide or an addition salt thereof with 1 -(2-bromoethoxy)-2-ethoxybenzene in a polar aprotic solvent in the presence of an organic base. More particularly, the invention relates to a process for preparing pure solid crystalline (R)(- )tamsulosin in its free base form as a precursor for the production of (R)(- )tamsulosin hydrochloride.

L'invention concerne de manière générale la préparation d'une base libre de tamsulosine. Plus particulièrement, l'invention concerne un procédé permettant de préparer de la tamsulosine cristalline solide pure sous sa forme de base libre à titre de précurseur destiné à la production de chlorhydrate de tamsulosine.

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