Process for the preparation of tetrazolyl compounds

Details Process for the preparation of tetrazolyl compounds Process for the preparation of tetrazolyl compounds

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/4184 (2006.01) A61P 9/00 (2006.01)

Patent

CA 2611293

The invention provides a method for preparing candesartan cilexetil and related tetrazolyl compounds. More particularly, the invention relates to the preparation of candesartan cilexetil and related tetrazolyl compounds and includes a method of removing a protective group (e.g., triphenylmethane (trityl) protecting group) from an N-protected tetrazolyl compound using a Lewis acid in an inert solvent and in the presence of an alcohol (e.g., reacting an N-protected tetrazolyl compound with ZnCl2 in the presence of an alcohol).

L~invention concerne un procédé de préparation de candésartan cilexétil et des composés tétrazolyle correspondants. Plus particulièrement, l'invention concerne la préparation du candésartan cilexétil et des composés tétrazolyle correspondants et comprend un procédé d~élimination d~un groupe protecteur (par exemple, un groupe protecteur triphénylméthane (trityle)) d'un composé tétrazolyle N-protégé en utilisant un acide de Lewis dans un solvant inerte et en présence d'un alcool (par exemple, par la réaction d~un composé tétrazolyle N-protégé avec ZnCl2 en présence d'un alcool).

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